Conference paper
The association between breast arterial calcifications observed on mammography and cardiovascular disease: preliminary results from an 18-year prospective study
P-29
The Menopause Society
2024 Annual Meeting of The Menopause Society (Chicago, Illinois, United States, 10 Sep 2024 - 14 Sep 2024)
Sep 2024
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Abstract
Objective: Cardiovascular disease (CVD) is the leading cause of mortality in women and is responsible for 1 in every 3 deaths each year in the United States. Despite this, existing cardiac risk assessment tools specific to women are lacking. Prior research has shown an association between the presence of breast arterial calcifications (BAC), which can be visualized on routine mammography and CVD. Therefore, this study aims to assess the longitudinal association between BAC and atherosclerotic CVD (ASCVD).
Design: Women were recruited at mammography centers in Connecticut. Data was collected on baseline demographics, race/ethnicity, menopause status, CVD risk factors (i.e. hypertension, diabetes, smoking), and family history of CVD. A follow-up survey at year 1, 2, 4, 5, 10 and 18- years was distributed to assess for the development of ASCVD risk factors and events. A Mantel-Cox test was performed to assess time to an ASCVD risk factor and event stratified by BAC status over all follow-up years. A Chi-square test was conducted to analyze the association between BAC and cumulative ASCVD events.
Results: At baseline 1,995 women completed the survey. The mean (±standard deviation) age was 56.3 (±12.1) years and 60.9% of women were menopausal. BAC was present on 14% of mammograms and 4.9% of women had known ASCVD at baseline. After 18 years of follow-up, 383 (19.2%) women completed the survey. Mantel-Cox analysis shows a significant association between BAC and freedom of an ASCVD event for participants with and without known ASCVD at baseline (p<0.001 and p<0.001, respectively). Mantel-Cox analysis revealed a significant association between BAC and freedom of an ASCVD risk factor in those with an ASCVD risk factor at baseline, and a non-significant association in those without an ASCVD risk factor at baseline (N [with BAC] = 268, N [without BAC] = 1651, p<0.001, p=0.149, respectfully). Cumulatively, women with BAC were more likely to experience ASCVD events over 18 years of follow-up (23% in those with BAC compared to 13.9% in those without, p<0.001).
Figure 1. A and B show Kaplan-Meier curves depicting Mantel-Cox analysis of time to development of CVD event stratified by BAC status including and excluding those with CVD at baseline, respectively (N [with BAC] = 268, N [without BAC] = 1651, p<0.001, p<0.001).
Conclusion: This study shows an association with BAC found on mammography and the development of both ASCVD events and risk factors over 18 years of prospective follow-up. These results suggest that the identification of BAC on routine mammography may serve as a marker for increased ASCVD risk in women over time. The presence of BAC on a mammogram should be routinely reported.
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Details
- Title
- The association between breast arterial calcifications observed on mammography and cardiovascular disease: preliminary results from an 18-year prospective study
- Creators
- Schyler Catherine Said - Drexel University, College of MedicineMaggie M Feng - Drexel University, College of MedicineHannah Elizabeth Daley - Drexel University, College of MedicineMarie Teresa Tan - Drexel University, College of MedicineJenna Elizabeth Ehlert - Drexel University, College of MedicineErica Helena Crawford - Drexel University, College of MedicineEmma J Christensen - Pennsylvania State UniversityMatthew Nudy - Pennsylvania State UniversityXuezhi Jiang - Reading HospitalPeter F Schnatz - Reading Hospital
- Publication Details
- P-29
- Conference
- 2024 Annual Meeting of The Menopause Society (Chicago, Illinois, United States, 10 Sep 2024 - 14 Sep 2024)
- Publisher
- The Menopause Society
- Resource Type
- Conference paper
- Language
- English
- Academic Unit
- College of Medicine; Obstetrics and Gynecology
- Identifiers
- 991021903712404721