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Targeting Neuroinflammation in Alcohol Use Disorder: A Review of Emerging Pharmacologic Therapies
Conference poster

Targeting Neuroinflammation in Alcohol Use Disorder: A Review of Emerging Pharmacologic Therapies

Kian Abolhoda, Keti Kutidze and Mustafa Kaghazwala
The American journal on addictions, v 35(2), pp 270-270
Mar 2026
DOI: https://doi.org/10.1111/ajad.70130 (p103)
PMID: 41742739
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Abolhoda-AmJAddict-AAAP-Targeting-2026-p270149.81 kB
Published, Version of Record (VoR) Access upon request

Abstract

Introduction Evidence about neuroinflammatory mechanisms contributing to the pathophysiology of schizophrenia continues to mount. This raises the question of whether anti-inflammatory drugs could offer therapeutic benefits. Aspirin (ASA) and statins, both widely utilized in various therapeutic settings, may provide a dual-purpose opportunity if proven effective in alleviating psychotic symptoms. This review explores the potential of ASA and statins as adjunctive treatments for schizophrenia. Methods The authors conducted a literature review of multiple scientific databases to find randomized control trials (RCTs) in English. Data related to medications, dosages, efficacy, and side effects were extracted. Results Minocycline has reduced alcohol intake and relapse in animals via microglial dampening, but clinical data are negative (Petrakis et al.). Ibudilast (PDE inhibitor, MIF modulator) shows mixed results: some trials found reduced craving, cue-reactivity, and heavy drinking(especially in women or those with depression), while others showed no overall effect on drinking or inflammation. N-acetylcysteine (NAC) reduces oxidative stress and glutamatergic dysregulation; a 2023 trial lowered drinks per drinking day but not heavy drinking days or abstinence. Takeaway: Findings are inconsistent. Lack of changes in peripheral inflammatory markers raises questions about central vs. systemic targeting. Subgroup signals (e.g., women, depressed patients) suggest benefit may depend on baseline characteristics and inflammatory profile, supporting stratified rather than broad application.

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