Conference presentation
A systems approach for the prediction of wild type MAPK pathway response to targeted drugs
07 Mar 2008
Abstract
In this paper we simulate the wild type MAPK pathway response to twelve in silico drugs that were previously found to reduce elevated phosphorylated ERK levels (ERK*) in 40 top ranked mutations in a model of the MAPK signal transduction pathway. We nd that a subset of the simulated drugs (notably those targeting GEF and the G G-protein trimer) were able to e ectively inhibit the elevated ERK* levels of the mutated pathways, whilst simultaneously eliciting only minimal inhibition of the wild type pathway ERK* response to EGF stimulation.
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Details
- Title
- A systems approach for the prediction of wild type MAPK pathway response to targeted drugs
- Creators
- David J. Miller - Drexel UniversityAvijit Ghosh - Drexel University
- Conference
- Eighth International Conference on Systems Biology, (Long Beach, California)
- Resource Type
- Conference presentation
- Language
- English
- Academic Unit
- Physics
- Other Identifier
- 991014632441404721