Conference presentation
Molecular health engineering: virtual reconstruction of intracellular biomolecular dynamics in clinical samples
Drexel University. School of Biomedical Engineering, Science, and Health Systems. Biomedical Technology Showcase, 2006.
21 Aug 2006
Abstract
Clinical Problem: Chronic diseases i.e. diabetes, COPD, caused by chronic inflammation, fundamentally alters the health of a cell at the molecular and cellular level. This reduced capacity is seen especially when exposed to acute inflammation from infections and trauma. Can "cell health" of people be "imaged" for diagnostic and therapeutic development? Engineering Challenge: Accurately and comprehensively visualize the dynamics of proteins and cells? Interdisciplinary Solution: Measure key components of "cell health", associated with cellular energetics, damage, apoptosis, necrosis in samples from patients. Data obtained exposing cells to in vitro perturbations are applied to estimate a dynamic "cell health" model that can be used as a "virtual" system to analyze and predict cellular changes in response to acute stress.
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Details
- Title
- Molecular health engineering: virtual reconstruction of intracellular biomolecular dynamics in clinical samples
- Creators
- Bahrad Ali Sokhansanj (Author) - Drexel University (1970-)Diane C. Lim (Author) - Drexel University (1970-)
- Publication Details
- Drexel University. School of Biomedical Engineering, Science, and Health Systems. Biomedical Technology Showcase, 2006.
- Resource Type
- Conference presentation
- Language
- English
- Academic Unit
- DU; School of Biomedical Engineering, Science, and Health Systems
- Identifiers
- 991014632934004721