Conference proceeding
20 kHz ultrasound assisted treatment of chronic wounds with concurrent optic monitoring
Micro- and Nanotechnology Sensors, Systems, and Applications VII, v 9467(January), 94670E
01 Jan 2015
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This paper describes a novel, wearable, battery powered ultrasound applicator that was evaluated as a therapeutic tool for healing of chronic wounds, such as venous ulcers. The low frequency and low intensity (similar to 100mW/cm(2)) applicator works by generating ultrasound waves with peak-to-peak pressure amplitudes of 55 kPa at 20 kHz. The device was used in a pilot human study (n=25) concurrently with remote optical (diffuse correlation spectroscopy -DCS) monitoring to assess the healing outcome. More specifically, the ulcers' healing status was determined by measuring tissue oxygenation and blood flow in the capillary network. This procedure facilitated an early prognosis of the treatment outcome and - once verified - may eventually enable customization of wound management. The outcome of the study shows that the healing patients of the ultrasound treated group had a statistically improved (p<0.05) average rate of wound healing (20.6%/week) compared to the control group (5.3%/week). In addition, the calculated blood flow index (BFI) decreased more rapidly in wounds that decreased in size, indicating a correlation between BFI and wound healing prediction. Overall, the results presented support the notion that active low frequency ultrasound treatment of chronic venous ulcers accelerates healing when combined with the current standard clinical care. The ultrasound applicator described here provides a user-friendly, fully wearable system that has the potential for becoming the first device suitable for treatment of chronic wounds in patient's homes, which - in turn - would increase patients' compliance and improve quality of life.
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Details
- Title
- 20 kHz ultrasound assisted treatment of chronic wounds with concurrent optic monitoring
- Creators
- Christopher R. Bawiec - Drexel UniversityYouhan Sunny - Drexel UniversityDavid Diaz - Drexel UniversitySumati Nadkarni - Drexel UniversityMichael S. Weingarten - Drexel UniversityMichael Neidrauer - Drexel UniversityDavid J. Margolis - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaLeonid Zubkov - Drexel UniversityPeter A. Lewin - Drexel University
- Publication Details
- Micro- and Nanotechnology Sensors, Systems, and Applications VII, v 9467(January), 94670E
- Conference
- Micro- and Nanotechnology Sensors, Systems, and Applications VII (Baltimore, Maryland, United States, 20 Apr 2015–24 Apr 2015)
- Series
- Proceedings of SPIE; 9467
- Publisher
- Spie-Int Soc Optical Engineering
- Number of pages
- 7
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- MD (Doctor of Medicine) Program; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000357259000009
- Scopus ID
- 2-s2.0-84937064550
- Other Identifier
- 991019169907004721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Electrical & Electronic
- Nanoscience & Nanotechnology
- Optics
- Physics, Applied