Conference proceeding
4D subharmonic imaging in vivo
2012 IEEE International Ultrasonics Symposium, pp 1106-1109
Oct 2012
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Subharmonic imaging (SHI) improves the isolation of ultrasound contrast agent signals from the surrounding tissue signals by transmitting at f 0 and receiving at f 0 /2. In this study we investigated the feasibility of generating real-time 3D (i.e., 4D) SHI volumes. Four-dimensional SHI (f 0 = 5.8 MHz, transmitting 4 cycle pulses) was implemented on a Logiq 9 ultrasound scanner with a mechanically controlled 4D10L probe (GE Healthcare, Milwaukee, WI). Experimental software provided access to both individual slice data and rendered images. This software also allowed imaging in B-mode (at 10 MHz) and harmonic imaging (HI; f 0 = 5 MHz, f receive = 10 MHz). Two canines received 5 μl/kg bolus injections of Definity (Lantheus Medical Imaging, N Billerica, MA) for HI and 20 μl/kg bolus for SHI of the lower renal pole. The contrast-to-tissue ratio was then calculated for three injections in each canine and compared between modes. Patients scheduled for biopsy of a mammographically identified breast lesion provided informed consent. Baseline scanning was performed in both B-mode and power Doppler. Patients then received a 0.25 ml bolus of Definity for HI followed by a bolus injection of 20 μl/kg for SHI. Baseline 2D cine loops, 3D slice data and rendered volumes were saved for off-line comparison. While scan volumes varied, a volume of 2.5 cm x 2.5 cm × 2.5 cm acquired at a 19° volume angle resulted in 45-50 slices per volume at an acquisition rate of 1.8 to 2.2 Hz depending on depth. In the canine model, SHI resulted in significant improvement in contrast visualization and rendered SHI images demonstrated superior tissue suppression and a greater overall view of renal vasculature. In breast lesions, enhancement varied greatly on a case by case basis. However, SHI resulted in improved tissue suppression and detection of contrast in almost all cases. Future work will explore the ability of 4D SHI to classify breast lesions.
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Details
- Title
- 4D subharmonic imaging in vivo
- Creators
- J. R Eisenbrey - Thomas Jefferson UniversityA Sridharan - Thomas Jefferson UniversityP Machado - Thomas Jefferson UniversityD. A Merton - Thomas Jefferson UniversityJ. B Liu - Thomas Jefferson UniversityK Wallace - GE Global ResearchS Park - GE Global Research (United States)S Dianis - GE Global ResearchC. L Chalek - GE Global ResearchK. E Thomenius - GE Global ResearchF Forsberg - Thomas Jefferson UniversityIEEE
- Publication Details
- 2012 IEEE International Ultrasonics Symposium, pp 1106-1109
- Publisher
- IEEE
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Health Management and Policy
- Web of Science ID
- WOS:000326960200229
- Scopus ID
- 2-s2.0-84882332131
- Other Identifier
- 991019173709904721
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- Web of Science research areas
- Engineering, Electrical & Electronic