Conference proceeding
A novel polymer-synthesized ceramic composite based system for bone repair: Osteoblast growth on scaffolds with varied calcium phosphate content
Nanoscale Materials Science in Biology and Medicine, v 845, pp 63-67
01 Jan 2005
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Polymer/ceramic composite matrices for bone tissue engineering were constructed by synthesizing a poorly crystalline calcium phosphate within poly(lactide-co-glycolide) microspheres that were subsequently fused together to form 3-dimensional structures. Calcium ion dissolution from the composite matrices in simulated body fluid was examined over a 24 hour period. The initial 4 hour period showed an increase in calcium ion concentration, whereas, a decrease in calcium ion concentration was noted thereafter. This decrease in concentration coincided with the precipitation of calcium phosphate on the surface of the matrices. Osteoblast proliferation studies on composite matrices showed statistically significant increases in cell number throughout the 21 day time period. These data together suggest that the composite matrix acts as both a calcium ion donor for reprecipitation of calcium phosphate that may enhance osteointegration of the implant, and a suitable surface for osteoblast proliferation.
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Details
- Title
- A novel polymer-synthesized ceramic composite based system for bone repair: Osteoblast growth on scaffolds with varied calcium phosphate content
- Creators
- Y M Khan - Drexel UniversityD S Katti - Indian Institute of Technology KanpurC T Laurencin - University of Virginia
- Publication Details
- Nanoscale Materials Science in Biology and Medicine, v 845, pp 63-67
- Conference
- Nanoscale Materials Science in Biology and Medicine (Boston, Massachusetts, United States, 28 Nov 2004–02 Dec 2004)
- Series
- MATERIALS RESEARCH SOCIETY SYMPOSIUM PROCEEDINGS
- Publisher
- Materials Research Society
- Number of pages
- 5
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000228804900010
- Other Identifier
- 991019339700904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Materials Science, Biomaterials
- Materials Science, Multidisciplinary