Conference proceeding
Alginate strings acting as a directional gradient in spinal cord regeneration
2003 IEEE 29th Annual Proceedings of Bioengineering Conference, pp 35-36
2003
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We are designing a spinal cord graft that would aid in directionally specific neuronal regeneration. We plan to use genetically engineered cells that release neurotrophic factors ensheathed in modified alginate strings. Thus far, we have a method for making strings of alginate bioconjugated with a laminin pentapeptide (YIGSR), which support cell adhesion. These strings are 400-500 /spl mu/m in thickness. In vitro studies have shown that rat (NB2a) and human (SHSY5Y) neuroblastoma cell lines adhere to, and differentiate on these modified alginate strings. Currently we are aiming to establish a growth factor gradient to promote neuronal differentiation in a desired direction. These modified alginate strings, when surgically transplanted in the spinal cord, would set up a physical gradient providing directional regeneration of the adherent neuronal cells.
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Details
- Title
- Alginate strings acting as a directional gradient in spinal cord regeneration
- Creators
- A Orana - Drexel UniversityS Kanakasabai - Drexel UniversityR MurphyM.A Wheatley
- Publication Details
- 2003 IEEE 29th Annual Proceedings of Bioengineering Conference, pp 35-36
- Conference
- 2003 IEEE 29th Annual Bioengineering Conference, 29th
- Publisher
- IEEE
- Number of pages
- 1
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Media Arts [Historical]
- Web of Science ID
- WOS:000184414900016
- Other Identifier
- 991019170613704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Computer Science, Artificial Intelligence
- Engineering, Biomedical
- Instruments & Instrumentation
- Radiology, Nuclear Medicine & Medical Imaging