Conference proceeding
Alkyl sulfate microbicidal activity in a commonly used vaginal preparation
XV INTERNATIONAL AIDS CONFERENCE: EPIDEMIOLOGY AND PREVENTION, pp.91-94
01 Jan 2004
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Our laboratory has previously published that common alkyl sulfates, including sodium dodecyl sulfate (SDS), have potent microbicidal activity. Inactivation of human immunodeficiency virus type 1 (HIV-1), human papillomaviruses (HPV) and herpes simplex virus type 2 (HSV-2) has been demonstrated for concentrations of 0.05% SDS, and above, as well as for other members of this chemical family (1). These compounds are readily biodegradable, broad spectrum and considerably less toxic than nonoxynol-9 (N9) despite possession of surfactant and chaotropic properties. This report demonstrates that a common proprietary vaginal preparation, available by prescription and containing SDS as an excipient, possesses potent microbicidal activity against the enveloped virus, HSV-2 and the non-enveloped, bovine papillomavirus.
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Details
- Title
- Alkyl sulfate microbicidal activity in a commonly used vaginal preparation
- Creators
- M K HowettE NeelyM WardS UrdanetaL FangMEDIMOND
- Publication Details
- XV INTERNATIONAL AIDS CONFERENCE: EPIDEMIOLOGY AND PREVENTION, pp.91-94
- Conference
- XV INTERNATIONAL AIDS CONFERENCE: EPIDEMIOLOGY AND PREVENTION, 15th
- Publisher
- Medimond Publishing Co
- Number of pages
- 4
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Identifiers
- 991019170332304721
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- Web of Science research areas
- Infectious Diseases
- Public, Environmental & Occupational Health
- Virology