Conference proceeding
CONTROLLED POROSITY OF CERAMIC SCAFFOLD BY DIRECTIONAL FREEZE CASTING AND SCAFFOLD PRINTING
PROCEEDINGS OF THE ASME/ISCIE INTERNATIONAL SYMPOSIUM ON FLEXIBLE AUTOMATION, ISFA 2012, pp.59-65
01 Jan 2013
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The objective of this work is to produce a 3-dimensional scaffold with hierarchical porosity produced with automated manufacturing control. In this paper we present a two-step manufacturing process: solid freeform fabrication (SFF) of a polymer scaffold, followed by freeze casting, a directional solidification technique, of composite slurry. This combination allows for the production of composite scaffolds with well defined, gradient porosity in two directions. Transverse porosity is created by immersing a printed alginate scaffold in a chitosan (CS)-hydroxyapatite (HA) slurry which is freeze cast to produce a scaffold with highly aligned porosity in the longitudinal direction. The combination of these two processes, printing and freeze casting, provides engineering control over chemical, structural and mechanical cues of the interconnected microenvironment within the scaffolds over several length scales, including features like overall porosity, pore size and shape as well as the choice of material and for example the ratio of polymer to ceramic within the highly porous composite material. Thus, the material's structure and architecture can be custom-designed by the fabrication processes to regulate diffusion throughout the scaffold as well as to potentially direct cell proliferation and migration.
Metrics
8 Record Views
Details
- Title
- CONTROLLED POROSITY OF CERAMIC SCAFFOLD BY DIRECTIONAL FREEZE CASTING AND SCAFFOLD PRINTING
- Creators
- Jessica Snyder - Drexel Univ, Philadelphia, PA 19104 USAPhilipp M. Hunger - Drexel Univ, Philadelphia, PA 19104 USAChengyang Wang - Drexel Univ, Philadelphia, PA 19104 USAUlrike G. K. WegstWei Sun - Drexel UniversityASME
- Publication Details
- PROCEEDINGS OF THE ASME/ISCIE INTERNATIONAL SYMPOSIUM ON FLEXIBLE AUTOMATION, ISFA 2012, pp.59-65
- Conference
- ASME/ISCIE INTERNATIONAL SYMPOSIUM ON FLEXIBLE AUTOMATION, ISFA 2012
- Publisher
- Amer Soc Mechanical Engineers
- Number of pages
- 7
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Identifiers
- 991019170554204721
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Web of Science research areas
- Automation & Control Systems
- Engineering, Mechanical