Conference proceeding
Classification of pharmaceutical toxicity by feature analysis
Proceedings of the IEEE 28th Annual Northeast Bioengineering Conference (IEEE Cat. No.02CH37342), v 2002-
2002
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The drug discovery process is far from optimal; only 1 in 10 compounds selected for development successfully reach the clinical trial phase. In an attempt to improve the efficiency of this process, we have applied feature analysis techniques to polypeptide spectral data from the liver of rats that have been exposed to various dosages of pharmaceuticals. Our goal is to use these techniques to predict the toxicity of a compound in vivo and help eliminate potentially dangerous pharmaceuticals from advancing past early stages of discovery.
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Details
- Title
- Classification of pharmaceutical toxicity by feature analysis
- Creators
- J Quinn - Drexel UniversityLit-Hsin LooJ ArmitageH CordingleyS RobertsP.J BugelskiM KamL Hrebien
- Publication Details
- Proceedings of the IEEE 28th Annual Northeast Bioengineering Conference (IEEE Cat. No.02CH37342), v 2002-
- Publisher
- IEEE
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- Electrical and Computer Engineering
- Web of Science ID
- WOS:000175970000106
- Other Identifier
- 991019346796004721
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- Web of Science research areas
- Engineering, Biomedical