Conference proceeding
Comparison of air and perfluorocarbon filled microbubbles for ultrasound contrast studies
1996 IEEE Ultrasonics Symposium. Proceedings, v 2, pp 1337-1340 vol.2
1996
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Abstract
To evaluate the impact of different gasses on contrast studies a new contrast agent ST68 (US patent 5,352,436) was produced with either air (ST68-Air) or perfluorocarbon (ST68-PFC) filled microbubbles. ST68 was administrated to 11 rabbits. In 4 animals a qualitative comparison of duration and degree of enhancement was performed. ST68-PFC produced greater vascular enhancement than did ST68-PFC, Also, the former achieved gray scale enhancement unlike the latter. Enhancement with ST68-PFC lasted over 8 minutes, while ST68-Air lasted less than 2 minutes. Quantitative dose-responses (averaged over 5 injections) were calculated, via spectral power analysis, using data from 7 rabbits and a 10 MHz cuff-transducer placed around the distal aorta. Maximum enhancement with ST68-Air was 18.3 dB for a 0.13 ml/kg dose, while ST68-PFC produced 26.1 dB of enhancement for a 0.1 ml/kg dose. In conclusion, perfluorocarbon filled microbubbles appear to be superior to air filled ones for use in an ultrasound contrast agent.
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Details
- Title
- Comparison of air and perfluorocarbon filled microbubbles for ultrasound contrast studies
- Creators
- F Forsberg - Thomas Jefferson University HospitalN.M RawoolD.A MertonJi-Bin LiuWenhua WangP KankateJ AlessandroB.B GoldbergM.A Wheatley
- Publication Details
- 1996 IEEE Ultrasonics Symposium. Proceedings, v 2, pp 1337-1340 vol.2
- Publisher
- IEEE
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:A1996BH56C00282
- Other Identifier
- 991019205315104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Acoustics
- Engineering, Electrical & Electronic
- Physics, Applied
- Polymer Science