Conference proceeding
Complexation Hydrogels for Stabilization of Peptidic HIV-1 Virucides
2012 38TH ANNUAL NORTHEAST BIOENGINEERING CONFERENCE (NEBEC), p422
Annual IEEE Northeast Bioengineering Conference
01 Jan 2012
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Human immunodeficiency virus 1 (HIV-1), the causative agent of acquired immune deficiency syndrome (AIDS), is a critical health priority. Although many therapies have been developed to slow the progression of AIDS, there are still no treatments available that can prevent or completely remove the infection. Recently, a highly potent, peptide triazole (PT) class of HIV-1 entry inhibitors has been identified that holds great promise for preventing HIV transmission. The purpose of this work is to enhance the in vivo stability of peptide triazoles by encapsulation in a pH-responsive hydrogel, composed of poly(methacrylic acid-g-ethylene glycol). Hydrogel loading and release of PT compositions are studied, and the stability of encapsulated PTs in enzymatic solutions is investigated.
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Details
- Title
- Complexation Hydrogels for Stabilization of Peptidic HIV-1 Virucides
- Creators
- P. L. Kubinski - Temple Univ, Dept Bioengn, Philadelphia, PA 19122 USAA. M. Lowman - Temple Univ, Dept Bioengn, Philadelphia, PA 19122 USAP. L. Kubinski - Temple Univ, Dept Bioengn, Philadelphia, PA 19122 USAC. Duffy - Drexel Univ, Coll Med, Dept Biochem & Mol Biol, Philadelphia, PA 19102 USAKantharaju - Drexel Univ, Coll Med, Dept Biochem & Mol Biol, Philadelphia, PA 19102 USAM. R. Contarino - Drexel Univ, Coll Med, Dept Biochem & Mol Biol, Philadelphia, PA 19102 USAI. Chaiken - Drexel UniversityIEEE
- Publication Details
- 2012 38TH ANNUAL NORTHEAST BIOENGINEERING CONFERENCE (NEBEC), p422
- Series
- Annual IEEE Northeast Bioengineering Conference
- Publisher
- IEEE
- Number of pages
- 2
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Identifiers
- 991019170366604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Engineering, Electrical & Electronic