Conference proceeding
Contrast-Enhanced Nonlinear 3D Ultrasound Imaging of Breast Lesions in a Clinical Population
2016 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), v 2016-
01 Jan 2016
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The ability to visualize breast lesion vascularity and quantify the vascular heterogeneity using contrast-enhanced 3-D nonlinear ultrasound imaging was investigated in a clinical population. Patients (n = 236) identified with breast lesions on mammography were scanned using power Doppler imaging, contrast-enhanced 3D HI, and 3D SHI on a modified Logiq 9 scanner (GE Healthcare). Time-intensity curve volumes were developed corresponding to ultrasound contrast agent flow in the lesions after being identified in 4D View (GE Medical Systems). Time points corresponding to, wash-in, baseline, peak intensity, and washout of ultrasound contrast agent were identified and used to generate and compare vascular heterogeneity plots for malignant and benign lesions. Vascularity was observed with power Doppler imaging in 93 lesions (69 benign and 24 malignant). The 3D HI showed flow in 8 lesions (5 benign and 3 malignant), whereas 3D SHI visualized flow in 83 lesions (58 benign and 25 malignant). Analysis of vascular heterogeneity in the 3D SHI volumes found benign lesions having a significant difference in vascularity between central and peripheral sections (1.8 +/- 0.16 vs. 1.2 +/- 0.09 dB, p = 0.0003, respectively), whereas malignant lesions showed no difference (1.7 +/- 0.33 vs. 1.3 +/- 0.21 dB, p = 0.23), indicative of more vascular coverage. Parametric volumes, that contained a single parametric value for every voxel within the 3D volume in order to visualize localized variations, were generated based on perfusion (PER) and area under the curve (AUC). These maps highlighted the variations in the vascularity for individual voxels in the lesion volume. Finally, a preliminary measure for lesion characterization, based on vascular heterogeneity, achieved an area under the ROC of 0.72. These preliminary results suggest quantitative evaluation of vascular heterogeneity in breast lesions using contrast-enhanced 3D SHI is feasible and able to detect variations in vascularity between central and peripheral sections for benign and malignant lesions to aid in characterization.
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Details
- Title
- Contrast-Enhanced Nonlinear 3D Ultrasound Imaging of Breast Lesions in a Clinical Population
- Creators
- Anush Sridharan - Thomas Jefferson UniversityJohn R. Eisenbrey - Thomas Jefferson UniversityMaria Stanczak - Thomas Jefferson UniversityAnnemarie Daecher - Thomas Jefferson UniversityPriscilla Machado - Thomas Jefferson UniversityAnnina Wilkes - Thomas Jefferson UniversityAlexander Sevrukov - Thomas Jefferson UniversityHaydee Ojeda-Fournier - University of California, San DiegoRobert F. Mattrey - University of California, San DiegoKirk Wallace - GE Global ResearchFlemming Forsberg - Thomas Jefferson UniversityIEEEMichael Stanczak - Interior Design
- Publication Details
- 2016 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), v 2016-
- Series
- IEEE International Ultrasonics Symposium
- Publisher
- IEEE
- Number of pages
- 4
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- Interior Design; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000387497400425
- Scopus ID
- 2-s2.0-84996598748
- Other Identifier
- 991019173567704721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Engineering, Electrical & Electronic