Conference proceeding
Cortical functional reorganization in response to intact forelimb stimulation from acute to chronic stage in rodent amputation model
2018 40TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), v 2018
01 Jan 2018
PMID: 30440331
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Brain plasticity after amputation is related to the short-term unmasking of latent synapses as well as the long-term reorganization due to the sprouting new synaptic connections. The cortical functional reorganization has been reported along the intact somatosensory pathway after unilateral deafferentation. Cerebral blood flow (CBF) change serves as an important biomarker of the functional reorganization of brain. Using laser speckle contrast imaging (LSCI) technology, we performed a longitudinal study to unveil the cortical functional reorganization after forelimb amputation in rodent model, particularly along the intact somatosensory pathway. Our results showed that the CBF response to electrical stimulation of the intact forepaw increased significantly at 9 hours after amputation in acute stage. While in chronic stage (> 14 days), the CBF response showed a pattern similar to the control group. The results showed the dynamic brain functional response along the intact somatosensory pathway at different stages after amputation and indicated that cortical functional reorganization occurred within the acute stage. Our work provided additional insights in understanding the inter- hemispheric functional changes from acute to chronic stages of amputation.
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Details
- Title
- Cortical functional reorganization in response to intact forelimb stimulation from acute to chronic stage in rodent amputation model
- Creators
- Yuanqi Li - Shanghai Jiao Tong UniversityYao Li - Shanghai Jiao Tong UniversityDaryl Omire-Mayor - Drexel UniversityBin Bo - Shanghai Jiao Tong UniversityHangdao Li - Shanghai Jiao Tong UniversityShanbao Tong - Shanghai Jiao Tong UniversityIEEE
- Publication Details
- 2018 40TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), v 2018
- Series
- IEEE Engineering in Medicine and Biology Society Conference Proceedings
- Publisher
- IEEE
- Number of pages
- 4
- Grant note
- 2011CB013304 / National Basic Research Program of China 61671292 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) 2016YFF0200700 / National Key R&D Program of China
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000596231900006
- Scopus ID
- 2-s2.0-85056622980
- Other Identifier
- 991019168971604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Engineering, Electrical & Electronic