Conference proceeding
Detection of heterogeneously expressed genes in cancer
2008 IEEE INTERNATIONAL WORKSHOP ON GENOMIC SIGNAL PROCESSING AND STATISTICS
IEEE International Workshop on Genomic Signal Processing and Statistics
01 Jan 2008
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Several mutations have been found to be heterogeneous throughout cancer samples. As an example, approximately 20% of lung cancer cases have a mutation in the protooncogene RAS. In order to specifically test for heterogeneous mutations we introduce a new test that measures differences between quantiles. It will be shown that this test can achieve larger power values than a previously published test by Coombes et al. when sample sizes are small (10-20 samples) and the probability of mutation is small (10%-40%). When applied to two publicly available microarray data sets our method also produces lists of results that are 12% and 27% the size of those produced by Coombes et al.
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Details
- Title
- Detection of heterogeneously expressed genes in cancer
- Creators
- Scott Haney - Drexel Univ, Data Fus Lab, Philadelphia, PA 19104 USAMoshe Kam - Drexel Univ, Data Fus Lab, Philadelphia, PA 19104 USALeonid Hrebien - Drexel UniversityIEEE
- Publication Details
- 2008 IEEE INTERNATIONAL WORKSHOP ON GENOMIC SIGNAL PROCESSING AND STATISTICS
- Series
- IEEE International Workshop on Genomic Signal Processing and Statistics
- Publisher
- IEEE
- Number of pages
- 3
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- Electrical and Computer Engineering
- Identifiers
- 991019170593804721
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