Conference proceeding
Development of a multi-frequency diffuse photon density wave device for the characterization of tissue damage at multiple depths
Advanced Biomedical and Clinical Diagnostic Systems XII, v 8935, 89351K
01 Jan 2014
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The ability to determine the depth and degree of cutaneous and subcutaneous tissue damage is critical for medical applications such as burns and pressure ulcers. The Diffuse Photon Density Wave (DPDW) methodology at near infrared wavelengths can be used to non-invasively measure the optical absorption and reduced scattering coefficients of tissue at depths of several millimeters. A multi-frequency DPDW system with one light source and one detector was constructed so that light is focused onto the tissue surface using an optical fiber and lens mounted to a digitally-controlled actuator which changes the distance between light source and detector. A variable RF generator enables the modulation frequency to be selected between 50 to 400MHz. The ability to digitally control both source-detector separation distance and modulation frequency allows for virtually unlimited number of data points, enabling precise selection of the volume and depth of tissue that will be characterized. Suspensions of Intralipid and india ink with known absorption and reduced scattering coefficients were used as optical phantoms to assess device accuracy. Solid silicon phantoms were formulated for stability testing. Standard deviations for amplitude and phase shift readings were found to be 0.9% and 0.2 degrees respectively, over a one hour period. The ability of the system to quantify tissue damage in vivo at multiple depths was tested in a porcine burn model.
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Details
- Title
- Development of a multi-frequency diffuse photon density wave device for the characterization of tissue damage at multiple depths
- Creators
- David Diaz - Drexel UniversityMichael S. Weingarten - Drexel UniversityMichael T. Neidrauer - Drexel UniversityJoshua A. Samuels - Drexel UniversityRichard B. Huneke - Drexel UniversityVladimir L. Kuzmin - Saint Petersburg State UniversityPeter A. Lewin - Drexel UniversityLeonid A. Zubkov - Drexel University
- Publication Details
- Advanced Biomedical and Clinical Diagnostic Systems XII, v 8935, 89351K
- Conference
- Advanced Biomedical and Clinical Diagnostic Systems XII (San Francisco, California, United States, 01 Feb 2014–06 Feb 2014)
- Series
- Proceedings of SPIE; 8935
- Publisher
- Spie-Int Soc Optical Engineering
- Number of pages
- 11
- Grant note
- 1002809 / National Science Foundation; National Science Foundation (NSF)
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- MD (Doctor of Medicine) Program; Microbiology and Immunology; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000335493700030
- Scopus ID
- 2-s2.0-84896927900
- Other Identifier
- 991019169655204721
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InCites Highlights
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- Collaboration types
- International collaboration
- Web of Science research areas
- Optics
- Radiology, Nuclear Medicine & Medical Imaging