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Development of biodegradable PLGA microspheres for use as ultrasound contrast agents
Conference proceeding

Development of biodegradable PLGA microspheres for use as ultrasound contrast agents

D El-Sherif and M.A Wheatley
Proceedings of the IEEE 27th Annual Northeast Bioengineering Conference (Cat. No.01CH37201)
2001

Abstract

Acoustic transducers Biodegradable materials Biological materials Biomedical engineering Chemical engineering Polymers Scanning electron microscopy Solvents Ultrasonic imaging Ultrasonic variables measurement
The authors have developed a method for producing hollow/porous poly (lactide co-glycolide) (PLGA) microcapsules with a mean size of 1 /spl mu/m by a modified double emulsion, solvent evaporation technique. Besides being biocompatible and biodegradable, these microspheres exhibit acoustic enhancements that make them useful as contrast agents for diagnostic imaging using ultrasound. Moreover, they are very stable and give a prolonged acoustic enhancement, as compared to other ultrasound contrast agents.

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Web of Science research areas
Engineering, Biomedical
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