Conference proceeding
Development of high yielding photonic light delivery system for photodynamic therapy of esophageal carcinomas
OPTICAL METHODS FOR TUMOR TREATMENT AND DETECTION: MECHANISMS AND TECHNIQUES IN PHOTODYNAMIC THERAPY XVI, v 6427(1), pp 642713-6427113
01 Jan 2007
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Photodynamic therapy (PDT) is an approved treatment modality for Barrett's and invasive esophageal carcinoma. Proper Combination of photosentizing agent, oxygen, and a specific wavelength of light to activate the photosentizing agents is necessary for the cytotoxic destruction of cancerous cells by PDT. As a light source expensive solid-state laser sources currently are being used for the treatment. Inexpensive semiconductor lasers have been suggested for the light delivery system, however packaging of semiconductor lasers for optimal optical power output is challenging. In this paper, we present a multidirectional direct water-cooling of semiconductor lasers that provides a better efficiency than the conventional unidirectional cooling. AlGaAsP lasers were tested under de-ionized (DI) water and it is shown that the optical power output of the lasers under the DI water is much higher than that of the uni-directional cooling of lasers. Also, in this paper we discuss how direct DI water-cooling can optimize power output of semiconductor lasers. Thereafter an optimal design of the semiconductor laser package is shown with the DI water-cooling system. Further, a microwave antenna is designed which is to be imprinted on to a balloon catheter in order to provide local heating of esophagus, leading to an increase in local oxygenation of the tumor to generate an effective level of singlet oxygen for cellular death. Finally the optimal level of light energy that is required to achieve the expected level of singlet oxygen is modeled to design an efficient PDT protocol.
Metrics
2 Record Views
Details
- Title
- Development of high yielding photonic light delivery system for photodynamic therapy of esophageal carcinomas
- Creators
- Amaranath Premasiri - Southern Methodist UniversityGemunu Happawana - Southern Methodist UniversityArye Rosen - Drexel University
- Contributors
- D Kessel (Editor)
- Publication Details
- OPTICAL METHODS FOR TUMOR TREATMENT AND DETECTION: MECHANISMS AND TECHNIQUES IN PHOTODYNAMIC THERAPY XVI, v 6427(1), pp 642713-6427113
- Series
- Proceedings of SPIE
- Publisher
- Spie-Int Soc Optical Engineering
- Number of pages
- 13
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- Electrical and Computer Engineering
- Web of Science ID
- WOS:000246489700026
- Scopus ID
- 2-s2.0-34548211411
- Other Identifier
- 991022065639504721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Oncology
- Optics