Conference proceeding
Dove: Shoulder-Based Opioid Overdose Detection and Reversal Device
IEEE International Conference on Connected Health: Applications, Systems and Engineering Technologies (CHASE)
01 Jan 2023
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Naloxone is a life-saving drug capable of reversing a fatal opioid overdose. Although this drug has existed for over 50 years, opioid overdose-related deaths have consistently risen and surpassed 120,000 globally in 2021. Opioids induce respiratory depression by activating mu-opioid receptors at specific sites in the central nervous system. This results in overdose deaths caused by slow and shallow breathing, also known as opioid-induced respiratory depression. 1.6 million individuals suffer from opioid use disorder annually, making them at high risk of overdose, primarily due to the increasing prevalence of Fentanyl. Over 52% of these deaths occur when the individual is alone. Immediate response to an overdose by delivering naloxone can save the individual's life. To solve this problem, we developed a closed-loop sensor-driven auto-injector that can determine a fatal overdose and inject naloxone. 76% of this population is willing to wear such a device on the shoulder, a canonical injection site. This paper presents the DOVE, a shoulder-based opioid overdose detection and reversal device. It noninvasively measures the subject's motion state and changes in blood oxygen levels (SpO(2)) along with the respiration state. These biomarkers are measured from the shoulder using an optical sensor and accelerometer to determine if a fatal overdose occurred. We evaluated our DOVE device against an FDA-cleared commercial pulse oximeter by inducing apneic events as they have very similar SpO(2) trends to an overdose. Results show that SpO(2) can be measured on the shoulder across different skin tones with an accuracy of 96.8% and a high Pearson correlation of 0.766 (p < 0.0001).
Metrics
Details
- Title
- Dove: Shoulder-Based Opioid Overdose Detection and Reversal Device
- Creators
- Anush Lingamoorthy - Drexel UniversityAmanda Watson - University of PennsylvaniaKorey Henderson - University of PennsylvaniaAyan Mandal - University of PennsylvaniaDavid Gordon - Thomas Jefferson UniversityXiaonan Ma - University of PennsylvaniaJames Weimer - Vanderbilt UniversityNagarajan Kandasamy - Drexel UniversityJacob S. Brenner - University of Pennsylvania
- Publication Details
- IEEE International Conference on Connected Health: Applications, Systems and Engineering Technologies (CHASE)
- Conference
- IEEE International Conference on Connected Health: Applications, Systems and Engineering Technologies (CHASE) (Orlando, Florida, United States, 21 Jun 2023–23 Jun 2023)
- Series
- IEEE International Conference on Connected Health-Applications, Systems and Engineering Technologies
- Publisher
- Assoc Computing Machinery
- Number of pages
- 12
- Grant note
- 284149 - 6905 / Coulter Foundation
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- Electrical and Computer Engineering; College of Engineering
- Web of Science ID
- WOS:001035594700006
- Scopus ID
- 2-s2.0-85167459806
- Other Identifier
- 991020989149604721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Computer Science, Cybernetics
- Computer Science, Interdisciplinary Applications
- Engineering, Biomedical
- Medical Informatics