Conference proceeding
Dynamic light scattering in veterinary medicine: refinement of diagnostic criteria
Proceedings of SPIE, v 4244(1), pp 552-560
01 Jan 2001
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In dynamic light scattering (DLS), the structure or material of interest, suspended in a fluid, is illuminated by a beam of laser light and the scattered light is interpreted in terms of diffusion coefficient, particle size or its distribution. DLS has shown clear promise as a non-invasive, objective and precise diagnostic modality for investigation of lens opacity (cataract) and other medical and toxicological problems. The clinical potential of LDS has been demonstrated in several species both in vivo and in vitro. In many clinical cases, discernment between normal and diseased patients is possible by simple inspection of the particle size distribution. However a more rigorous and sensitive classification scheme is needed, particularly for evaluation of therapy and estimation of tissue injury. The data supplied by DLS investigation is inherently multivariate and its most efficient interpretation requires a multivariate approach which includes the variability among specimens as well as any correlation among the variables (e.g. across the particle size distribution). We present a brief review of DLS methodology, illustrative data and our efforts toward a diagnostic classification scheme. In particular we will describe application of the Mahalanobis distance and related statistical methods to DLS data.
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Details
- Title
- Dynamic light scattering in veterinary medicine: refinement of diagnostic criteria
- Creators
- Stephen Dubin - University of the SciencesStanley Zietz - University of the SciencesKarl L Gabriel - ConTox Ltd. (USA)David Gabriel - ConTox Ltd. (USA)Michael A DellaVecchia - Wills Eye HospitalRafat R Ansari - Glenn Research Center
- Publication Details
- Proceedings of SPIE, v 4244(1), pp 552-560
- Conference
- Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI
- Publisher
- Society of Photo-Optical Instrumentation Engineers (SPIE)
- Number of pages
- 9
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; [Retired Faculty]
- Web of Science ID
- WOS:000169641700074
- Scopus ID
- 2-s2.0-0034931225
- Other Identifier
- 991021902594704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Biomedical
- Optics
- Physics, Applied
- Surgery