Conference proceeding
EFFECTS OF PROCESS PARAMETERS ON CELL DAMAGE IN A 3D CELL PRINTING PROCESS
IMECE2009: PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, VOL 2, v 2, pp 75-81
01 Jan 2010
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Various types of bio-fabrication methods have been developed to manufacture products with living cells incorporated via mechanical means. One of fundamental questions that need to be answered is whether cells remain viable and/or functional when subjected to these mechanical disturbances. In this paper, we focus on a 3D cell-printing process via pressure induced deposition. Our experimental studies show that process parameters such as pressure applied and nozzle size affect the cell viability. Given that the cells are suspended in the alginate solution during the printing process, Computational Fluid Dynamic (CFD) analysis is employed to model the pressure-driven flow system and determine the local environment that the living cells are in under varying process parameters. Effects of obtained wall shear stress and exposure time are examined in terms of cell damage based on the corresponding experimental data.
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Details
- Title
- EFFECTS OF PROCESS PARAMETERS ON CELL DAMAGE IN A 3D CELL PRINTING PROCESS
- Creators
- Karen Chang Yan - College of New JerseyKamila Paluch - College of New JerseyKalyani Nair - Bradley UniversityWei Sun - Drexel UniversityASME
- Publication Details
- IMECE2009: PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, VOL 2, v 2, pp 75-81
- Conference
- IMECE2009: ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION
- Publisher
- Amer Soc Mechanical Engineers
- Number of pages
- 7
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000282340500013
- Scopus ID
- 2-s2.0-77954326607
- Other Identifier
- 991019173669204721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biotechnology & Applied Microbiology
- Engineering, Biomedical
- Engineering, Mechanical