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EFFECTS OF SCAFFOLD DESIGN PARAMETERS AND LOCAL ENVIRONMENT ON BIOPOLYMER SCAFFOLD DEGRADATION
Conference proceeding

EFFECTS OF SCAFFOLD DESIGN PARAMETERS AND LOCAL ENVIRONMENT ON BIOPOLYMER SCAFFOLD DEGRADATION

Karen Chang Yan, Christina Roros, Maria Swift, Wei Sun and ASME
IMECE2009: PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, VOL 2, v 2, pp 25-26
01 Jan 2010

Abstract

Biotechnology & Applied Microbiology Engineering Engineering, Biomedical Engineering, Mechanical Life Sciences & Biomedicine Science & Technology Technology
Biodegradable polymers have been extensively used in tissue engineering as temporary porous scaffolding structures to host or guide tissue/organ regeneration. The advantage lies in that the polymers degrade away harmlessly in the body. One key requirement in tissue scaffold design is to control the scaffolding degradation and erosion that synchronize the new cell/tissue growth. The degradation and/or erosion for biodegradable polymers are influenced by a multitude of factors. This paper presents an in vitro experimental study to examine effects of scaffold design parameters and local environment on the degradation rate of biopolymer scaffolds. Parameters considered are scaffold pore size, material composition and cellular activity.

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Web of Science research areas
Biotechnology & Applied Microbiology
Engineering, Biomedical
Engineering, Mechanical
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