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Effect of Model Microgravity on Human Hepatic Pharmacokinetics and Urea Secretion
Conference proceeding

Effect of Model Microgravity on Human Hepatic Pharmacokinetics and Urea Secretion

J. E. Snyder, K. Emami, B. Du, Y. Zhang, H. Wu, W. Sun and IEEE
2012 38TH ANNUAL NORTHEAST BIOENGINEERING CONFERENCE (NEBEC)
Annual IEEE Northeast Bioengineering Conference
01 Jan 2012

Abstract

Engineering Engineering, Biomedical Engineering, Electrical & Electronic Science & Technology Technology
3-Dimensional hepatocyte aggregates experience simulated microgravity in a Rotary Cell Culture System (RCCS). Pharmacokinetic rate and urea secretion are up-regulated in model microgravity. This work has application to space life sciences and clinical dosing requirements for long term manned space exploration.

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Web of Science research areas
Engineering, Biomedical
Engineering, Electrical & Electronic