Conference proceeding
Effect of Nanosecond Pulsed Atmospheric Pressure Dielectric Barrier Discharges on Immune Cell Mediated Wound Healing
The Institute of Electrical and Electronics Engineers, Inc. (IEEE) Conference Proceedings, 1
01 Jan 2017
Abstract
Conference Title: 2017 IEEE International Conference on Plasma Science (ICOPS) Conference Start Date: 2017, May 21 Conference End Date: 2017, May 25 Conference Location: Atlantic City, NJ, USA We have previously shown that Reactive Oxygen species and charges in atmospheric pressure nanosecond pulsed dielectric barrier discharges (nspDBD) stimulate immune function both in vitro and in vivoto enhance their migration, produce cytokines and kill tumor cells. (1–3) The immune cells act as “transport mechanis” for tumor killing effect of plasma so that deep tumors that are not directly accessible to plasma are also resolved. (4) Tumor growth is controlled not by plasma directly but by the action of plasma-activated immune cells. (4) Cells of the immune system also play an important role at all stages of wound healing. In the acute phase control of infection and inflammation is important. Their contribution in the late stages involves reepithelialization and angiogenesis to accelerate healing and reduce scar formation. (5, 6) Several studies suggest that plasma also benefits the process of wound healing. (7) However, the contribution of immune cells in plasma-mediated wound healing has not been studied. In this study we used the in vitro scratch assay to study if plasma improves wound healing through interaction with immune cells. In addition, the effect of bacterial infection on the healing process by plasma was examined. The implications of plasma stimulation of immune function for deep wound healing will be discussed.
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Details
- Title
- Effect of Nanosecond Pulsed Atmospheric Pressure Dielectric Barrier Discharges on Immune Cell Mediated Wound Healing
- Creators
- Yulia MalkovaMeng Yu ZhuSean SmithAlexander FridmanVandana Miller
- Publication Details
- The Institute of Electrical and Electronics Engineers, Inc. (IEEE) Conference Proceedings, 1
- Publisher
- The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- Microbiology and Immunology; Mechanical Engineering and Mechanics
- Identifiers
- 991019170140304721