Conference proceeding
Effect of mechanical trauma on neuronal cell viability
Proceedings of the IEEE 27th Annual Northeast Bioengineering Conference (Cat. No.01CH37201)
2001
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To understand the cellular mechanisms of neuronal injury, it is very important to mimic the mechanical loading conditions experienced by the cells in vivo. A cell culture model is an idealized system to investigate cell injury at the cellular and molecular levels. The authors developed a model that allows mechanical stimuli to be precisely controlled and cellular responses to be quantified. In this study, shear stress was dynamically applied to PC2 cells and cell viability assessed at 24 hours. Dynamic mechanical loading of cells produced graded levels of injury as assessed by long-term viability. This system can now be used to investigate further the mechanism of the injury and to assess various treatments of neuronal injury and subsequent degeneration.
Metrics
14 Record Views
Details
- Title
- Effect of mechanical trauma on neuronal cell viability
- Creators
- G Serbest - Drexel UniversityJ HorwitzK.A Barbee
- Publication Details
- Proceedings of the IEEE 27th Annual Northeast Bioengineering Conference (Cat. No.01CH37201)
- Conference
- IEEE 27th Annual Northeast Bioengineering Conference, 27th
- Publisher
- IEEE
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- Pharmacology and Physiology; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000169191600017
- Other Identifier
- 991019169617404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Biomedical