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Effect of polymer composition on in vivo ultrasound contrast agent performance
Conference proceeding

Effect of polymer composition on in vivo ultrasound contrast agent performance

J.D Lathia, N.T Le, D El-Sherif, F Forsberg, Jin-Bin Liu, D.A Merton, M Shimizu, B.B Goldberg and M.A Wheatley
2003 IEEE 29th Annual Proceedings of Bioengineering Conference, v 2003-, pp 323-324
2003
DOI: https://doi.org/10.1109/NEBC.2003.1216126
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Acoustic testing Biomedical acoustics Biomedical engineering Chemical engineering Degradation In vivo Polymers Rabbits System testing Ultrasonic imaging
Polymer composition, the ratio of lactic acid (LA) to glycolic acid (GA), was evaluated for its contribution to the acoustic enhancement of a poly (co-lactic-glycolic) acid (PLGA) ultrasound contrast agent. Contrast agents were prepared from four different polymer compositions (LA:GA): 100:0, 85:15, 75:25, 50:50 and tested in vivo. The results indicate that all contrast agents perform well in vivo but the 50:50, which had the shortest usable life-time. The performance of the contrast agents was dependent on the ratio of LA to GA and should be considered in the design of polymeric contrast agents.

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Web of Science research areas
Computer Science, Artificial Intelligence
Engineering, Biomedical
Instruments & Instrumentation
Radiology, Nuclear Medicine & Medical Imaging
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