Conference proceeding
Evaluating surrogate markers
Journal of acquired immune deficiency syndromes and human retrovirology, v 10(SUP2), pp S1-S8
01 Jan 1995
PMID: 7552506
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We discuss approaches for efficiently evaluating potential surrogate markers; in particular, we focus on case-cohort designs in which marker evaluation is undertaken only for a random sample of subjects within a randomized trial and for all other subjects who develop a major clinical outcome. These designs will be useful in clinical trials in which a highly significant treatment difference on clinical outcome has been obtained. In addition, we describe a method for using data from all available studies using a meta-analysis to explore the association of treatment effects on the potential marker and on clinical outcome. This may be the most effective approach for marker evaluation because it uses data from both large and small trials and incorporates information from trials in which nonsignificant treatment differences on the major clinical outcome are obtained.
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Details
- Title
- Evaluating surrogate markers
- Creators
- M. D Hughes - Harvard UniversityV Degruttola - Harvard UniversityS. L Welles - Harvard University
- Publication Details
- Journal of acquired immune deficiency syndromes and human retrovirology, v 10(SUP2), pp S1-S8
- Conference
- Surrogate markers of HIV : strategies and issues for selection and use. Symposium
- Publisher
- Raven Press
- Number of pages
- 8
- Grant note
- Glaxo-Wellcome
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:A1995TD18600002
- Scopus ID
- 2-s2.0-0029176778
- Other Identifier
- 991021012815104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Infectious Diseases