Conference proceeding
Experimental methods for ultrasonically enhanced wound healing
1994 Proceedings of IEEE Ultrasonics Symposium, v 3, pp 1853-1856 vol.3
1994
Abstract
An initial study into the synergistic effects of combining therapeutic ultrasound insonation and collagen treatments was conducted. Experimental methods were developed to: 1) provide uniform, calibrated ultrasound exposure, including transducer design, calibration, positioning, and alignment; 2) insure ultrasound coupling into wound sites; 3) create uniform wounds of the proper size and depth; and 4) accurately characterize the mechanical properties of the healed wounds. Full thickness wounds of 1.5 cm in diameter were used in adult Yucatan mini-pigs with an experiment duration of 21 days. A custom ultrasound exposure system was used operating at 0.75 MHz and 100 mW/cm 2 (ISATA) output intensity. Wound areas were treated with ultrasound for 5 minutes daily. Histological evaluation indicated that: 1) collagen treatment produced more cellular organization; and 2) ultrasound treatment reduced inflammatory response. In-vitro mechanical testing showed: 1) ultrasound treatment combined with either the collagen bead suspension or a saline dressing produced stronger and tougher healing tissues; and 2) ultrasound treatment combined with a hydrocolloid dressing resulted in weaker and more fragile tissues
Metrics
3 Record Views
Details
- Title
- Experimental methods for ultrasonically enhanced wound healing
- Creators
- M SchaferS DubinA GeshuryF Ko
- Publication Details
- 1994 Proceedings of IEEE Ultrasonics Symposium, v 3, pp 1853-1856 vol.3
- Publisher
- IEEE
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; [Retired Faculty]
- Web of Science ID
- WOS:A1994BC66H00380
- Scopus ID
- 2-s2.0-0028740648
- Other Identifier
- 991019182774704721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Acoustics
- Engineering, Biomedical
- Engineering, Electrical & Electronic
- Engineering, Mechanical
- Remote Sensing
- Telecommunications