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Experimental methods for ultrasonically enhanced wound healing
Conference proceeding

Experimental methods for ultrasonically enhanced wound healing

M Schafer, S Dubin, A Geshury and F Ko
1994 Proceedings of IEEE Ultrasonics Symposium, v 3, pp 1853-1856 vol.3
1994
DOI: https://doi.org/10.1109/ULTSYM.1994.401951

Abstract

Acoustic radiation effects Animals Biological effects of acoustic radiation Biological tissues Biomechanics Biomedical applications of acoustic radiation Biomedical transducers
An initial study into the synergistic effects of combining therapeutic ultrasound insonation and collagen treatments was conducted. Experimental methods were developed to: 1) provide uniform, calibrated ultrasound exposure, including transducer design, calibration, positioning, and alignment; 2) insure ultrasound coupling into wound sites; 3) create uniform wounds of the proper size and depth; and 4) accurately characterize the mechanical properties of the healed wounds. Full thickness wounds of 1.5 cm in diameter were used in adult Yucatan mini-pigs with an experiment duration of 21 days. A custom ultrasound exposure system was used operating at 0.75 MHz and 100 mW/cm 2 (ISATA) output intensity. Wound areas were treated with ultrasound for 5 minutes daily. Histological evaluation indicated that: 1) collagen treatment produced more cellular organization; and 2) ultrasound treatment reduced inflammatory response. In-vitro mechanical testing showed: 1) ultrasound treatment combined with either the collagen bead suspension or a saline dressing produced stronger and tougher healing tissues; and 2) ultrasound treatment combined with a hydrocolloid dressing resulted in weaker and more fragile tissues

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Web of Science research areas
Acoustics
Engineering, Biomedical
Engineering, Electrical & Electronic
Engineering, Mechanical
Remote Sensing
Telecommunications
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