Logo image
Back
Fiber optic system for in-vivo sizing of proteins in animal eye lenses
Conference proceeding

Fiber optic system for in-vivo sizing of proteins in animal eye lenses

Harbans S Dhadwal, Rafat R Ansari, Michael A DellaVecchia and Stephen Dubin
Proceedings of SPIE, v 2393(1), pp 227-236
22 May 1995
DOI: https://doi.org/10.1117/12.209855
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

A compact fiber optic system, utilizing a lensless backscatter fiber optic probe, and a semiconductor laser is used as a non-invasive tool for in vivo characterization of the proteins in the eye lens of several animals. The system exploits the extremely sensitive technique of dynamic light scattering, which uses a laser beam to probe the temporal characteristics of the proteins present in eye lens fluid. The technique, with appropriate electronics and signal processing provides a rapid means of determining the size of the (alpha) -crystallin in the protein-water system. Changes in the size of the protein molecules can be tracked over the age of the eye lens; an abrupt increase in size is associated with the early cataractous formation. This paper describes the fiber optic system and discusses results obtained from measurements made on sedated rabbits, pigs and cats. A clear difference in the size of the (alpha) -crystallin of normal and cataractous lenses is observed.

Metrics

17 Record Views
1 citations in Web of Science
1 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Web of Science research areas
Ophthalmology
Optics
Logo image