Conference proceeding
Flow attachment assessment of a peptide-conjugated polymeric contrast agent for targeted ultrasound imaging
2003 IEEE 29th Annual Proceedings of Bioengineering Conference, v 2003-, pp 164-165
2003
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Fibronectin peptide fragments were conjugated to PIA ultrasound contrast agents to develop a targeted contrast agent that enhances ultrasound imaging. The microspheres were coated with generic GRGDS and REDV peptide sequences that target integrins expressed in angiogenesis, /spl alpha//sub v//spl beta//sub 3/ and /spl alpha//sub v//spl beta//sub 5/. The microspheres bound to human breast cancer cells in vitro within 3 minutes under flow conditions. The GRGDS and REDV peptide modified microspheres show promise as candidates for targeted therapeutic imaging and eventually drug delivery vehicles.
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Details
- Title
- Flow attachment assessment of a peptide-conjugated polymeric contrast agent for targeted ultrasound imaging
- Creators
- J.D Lathia - Drexel UniversityB.E Oeffinger - Drexel UniversityK.A Barbee - Drexel UniversityM.A Wheatley - Drexel University
- Publication Details
- 2003 IEEE 29th Annual Proceedings of Bioengineering Conference, v 2003-, pp 164-165
- Publisher
- IEEE
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000184414900080
- Other Identifier
- 991019170581804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Computer Science, Artificial Intelligence
- Engineering, Biomedical
- Instruments & Instrumentation
- Radiology, Nuclear Medicine & Medical Imaging