Conference proceeding
IL-1 beta production by differentiating TF-1 bone marrow progenitor cells
8TH INTERNATIONAL CONGRESS OF NEUROIMMUNOLOGY, pp.353-359
01 Jan 2006
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Human immunodeficiency virus type I (HIV-1) gains access to the central nervous system (CNS) through infected monocytes, which originate in the bone marrow and are able to cross the blood brain barrier (BBB). Bone marrow monocyte progenitors are refractory to HIV-1 infection and it is unclear at what stage of their differentiation they become susceptible. The TF-1 bone marrow progenitor cell line was selected as a model to study HIV-1 infection during the differentiation process of hematopoietic progenitor cells. We have shown that conditioned medium from PMA-treated TF-1 cells is able to induce differentiation of untreated TF-1 cells. Herein, we proceeded to determine what factors are present in the conditioned medium that may be responsible for its activating/differntiating role.
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Details
- Title
- IL-1 beta production by differentiating TF-1 bone marrow progenitor cells
- Creators
- A. Alexaki - Drexel Univ, Inst Mol Med & Infect Dis, Ctr Mol Virol & Neuroimmunol, Coll Med,Dept Microbiol & Immunol, Philadelphia, PA 19129 USAA. Banerjee - Drexel UniversityE. Kilareski - Drexel Univ, Inst Mol Med & Infect Dis, Ctr Mol Virol & Neuroimmunol, Coll Med,Dept Microbiol & Immunol, Philadelphia, PA 19129 USAM. Nonnernacher - Drexel Univ, Inst Mol Med & Infect Dis, Ctr Mol Virol & Neuroimmunol, Coll Med,Dept Microbiol & Immunol, Philadelphia, PA 19129 USAB. Wigdahl - Drexel University
- Contributors
- T Tabira (Editor)T Yamamura (Editor)J Kira (Editor)
- Publication Details
- 8TH INTERNATIONAL CONGRESS OF NEUROIMMUNOLOGY, pp.353-359
- Conference
- 8TH INTERNATIONAL CONGRESS OF NEUROIMMUNOLOGY, 8th
- Publisher
- Medimond S R L
- Number of pages
- 7
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- Decision Sciences (and Management Information Systems); Microbiology and Immunology
- Identifiers
- 991019170331504721
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- Web of Science research areas
- Immunology
- Neurosciences