Conference proceeding
INTERACTIONS OF POLOXAMER HYDROGEL COMPOSITES CONTAINING CARBON NANOBRUSHES WITH CLINICALLY RELEVANT CELL LINES
PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B, pp 771-772
01 Jan 2012
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The objective of this work is to study the interactions of an electrically conductive hydrogel composite with different clinically relevant cell lines. The composite is comprised of carbon nanobrushes embedded in a biocompatible poloxamer gel. This work assesses the ability of such composite gels to support the growth of fibroblasts and myoctes and eventually serve as a matrix to stimulate wound closure. In such a model, fibroblasts and myocytes are seeded separately on the composite hydrogel and bathed in culture medium. The experimental model assesses the ability of fibroblasts and myocytes to grow into and adhere to the gel containing carbon nanobrushes. The work demonstrates that carbon nanobrushes can be dispersed within poloxamer gels, and that fibroblasts and myoctyes can proliferate within a poloxamer gel containing homogenously dispersed carbon nanobrushes. Future work will additionally examine the effects of design parameters such as carbon nanobrush content and matrix structure on wound healing, as well as the growth of tendons and other cell lines within the hydrogel composites. This work has relevance for tissue engineering and tissue regeneration in clinical medicine.
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4 citations in Scopus
Details
- Title
- INTERACTIONS OF POLOXAMER HYDROGEL COMPOSITES CONTAINING CARBON NANOBRUSHES WITH CLINICALLY RELEVANT CELL LINES
- Creators
- William H. Marks - Harvard University PressSze C. Yang - University of Rhode IslandGeorge W. Dombi - University of Rhode IslandSujata K. Bhatia - Harvard University PressASME
- Publication Details
- PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B, pp 771-772
- Publisher
- Amer Soc Mechanical Engineers
- Number of pages
- 2
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000325036600385
- Scopus ID
- 2-s2.0-84882575292
- Other Identifier
- 991021230006904721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Biomedical
- Engineering, Mechanical