Conference proceeding
In Vitro 3-D Culture Model of Tumor Cell Compression
2012 38TH ANNUAL NORTHEAST BIOENGINEERING CONFERENCE (NEBEC), pp.293-294
Annual IEEE Northeast Bioengineering Conference
01 Jan 2012
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Recently, research has begun to focus on the effects of forces from the tumor expanding against native tissue. The effect of tumor growth in such an environment has been implicated in tumor latency and metastasis. Thus, there is a need for a cost-effective in vitro research tool that applies compression to model solid stress in the tumor environment and is compatible with live cell microscopy. The device will apply deformation to a 3-D gel in a chambered cover glass slide over a range of strains (10-50%). The device must also be biocompatible and stable in cell culture environments. In addition, it must have an unobstructed light path and fit within the specified microscope. A prototype is currently being fabricated and cytotoxicity is being evaluated.
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Details
- Title
- In Vitro 3-D Culture Model of Tumor Cell Compression
- Creators
- P. Tomezsko - Drexel Univ, Philadelphia, PA 19104 USAD. Kyryliouk - Drexel Univ, Philadelphia, PA 19104 USAP. Sharma - Drexel Univ, Philadelphia, PA 19104 USAA. Morgano - Drexel Univ, Philadelphia, PA 19104 USAA. Shieh - Drexel UniversityIEEE
- Publication Details
- 2012 38TH ANNUAL NORTHEAST BIOENGINEERING CONFERENCE (NEBEC), pp.293-294
- Series
- Annual IEEE Northeast Bioengineering Conference
- Publisher
- IEEE
- Number of pages
- 2
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Identifiers
- 991019170502204721
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InCites Highlights
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- Web of Science research areas
- Engineering, Biomedical
- Engineering, Electrical & Electronic