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In vitro and in vivo characterization of a new surfactant stabilized ultrasound contrast media
Conference proceeding

In vitro and in vivo characterization of a new surfactant stabilized ultrasound contrast media

F Forsberg, Y.Q Wu, I.R.S Makin, J Srinivasan, Wenhua Wang and M.A Wheatley
1995 IEEE Ultrasonics Symposium. Proceedings. An International Symposium, v 2, pp 1129-1132 vol.2
1995
DOI: https://doi.org/10.1109/ULTSYM.1995.495759

Abstract

Apertures Attenuation Backscatter Chemical engineering In vitro In vivo Nonlinear acoustics Radio frequency Radiology Ultrasonic imaging
Quantitative characterization of a new ultrasound contrast media ST68 has been performed, ST68 is a sonicated mixture of nonionic surfactants (Span-type and Tween-type), consisting of stabilized microbubbles with a mean diameter of 3.8 /spl mu/m and a concentration of 7.1/spl times/10/sup 8/ bubbles/mL. In vitro a pulsatile flow system was used to acquire digitized RF A-lines. The acoustic properties of ST68, as a function of time, frequency and dose, were calculated. Backscatter changed nonlinearly with dose; maximum was 12.5 dB/spl plusmn/1.0 dB for a 0.4 mL dose. Attenuation reached approximately 22.5 dB/cm for dosages above 0.4 mL. In vivo intravenous injections were given to three rabbits (dosage: 0.01-0.23 mL/kg). A clear increase in flow signal intensity was observed for 1-2 minutes. An in vivo dose response curve was calculated from the audio signals of a 10 MHz cuff transducer placed around the distal aorta. Maximum enhancement was 18.3 dB/spl plusmn/3.13 dB for a 0.13 mL/kg dose. In conclusion, ST68 is capable of producing marked vascular enhancement. Its acoustic properties have been characterized in vitro and in vivo.

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Web of Science research areas
Engineering, Electrical & Electronic
Instruments & Instrumentation
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