Conference proceeding
In vitro and in vivo testing of PLGA contrast agents
Proceedings of the IEEE 28th Annual Northeast Bioengineering Conference (IEEE Cat. No.02CH37342), v 2002-, pp 229-230
2002
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Abstract
We have optimized a method for producing hollow poly (lactide-co-glycolide) (PLGA) microcapsules with a mean size of 1 /spl mu/m by a modified double emulsion, solvent evaporation technique. Besides being biocompatible and biodegradable, these microspheres exhibit acoustic enhancements that makes them useful as contrast agents for diagnostic ultrasound imaging. In vivo studies (rabbit) demonstrate significant enhancement of power Doppler images. Moreover, the capsules' solid shells makes them ideal candidates for the use as drug delivery vehicles for targeted/triggered therapeutic imaging.
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Details
- Title
- In vitro and in vivo testing of PLGA contrast agents
- Creators
- D El-Sherif - Drexel UniversityM.A Wheatley
- Publication Details
- Proceedings of the IEEE 28th Annual Northeast Bioengineering Conference (IEEE Cat. No.02CH37342), v 2002-, pp 229-230
- Publisher
- IEEE
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000175970000115
- Other Identifier
- 991019168301904721
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- Web of Science research areas
- Engineering, Biomedical