Conference proceeding
Influence of Microbubble Shell Chemistry on the Destruction Threshold of Ultrasound Contrast Agent Microbubbles
ACOUSTICAL IMAGING, VOL 31, v 31, pp 91-101
01 Jan 2012
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Abstract
The destruction threshold of ultrasound contrast agents is an important parameter for safety and applications in targeted drug delivery. Since this threshold is a function of the chemical composition of lipid-shelled microbubbles, adjustment of this composition may allow tuning of the destruction threshold. To attain this goal, this study presents a framework for the analysis of the destruction threshold. A method for the theoretical determination of this threshold is presented. Theoretical results are subsequently validated by experiments, yielding a linear dependence between shell viscosity and elasticity and DSPE-PEG2000 concentration.
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Details
- Title
- Influence of Microbubble Shell Chemistry on the Destruction Threshold of Ultrasound Contrast Agent Microbubbles
- Creators
- Michal Mleczko - Ruhr Univ Bochum, Inst Med Engn, Univ Str 150, Bochum, GermanyStephen M. Dicker - Drexel UniversitySteven P. Wrenn - Drexel UniversityGeorg Schmitz - Ruhr University Bochum
- Contributors
- A Nowicki (Editor)J Litniewski (Editor)T Kujawska (Editor)
- Publication Details
- ACOUSTICAL IMAGING, VOL 31, v 31, pp 91-101
- Series
- Acoustical Imaging
- Publisher
- Springer Nature
- Number of pages
- 11
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- Chemical and Biological Engineering
- Web of Science ID
- WOS:000312533900010
- Other Identifier
- 991019167445004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Acoustics
- Radiology, Nuclear Medicine & Medical Imaging