Conference proceeding
Interstitial flow drives CXCR4-dependent hepatocellular carcinoma cell invasion
2012 38TH ANNUAL NORTHEAST BIOENGINEERING CONFERENCE (NEBEC), pp.43-44
Annual IEEE Northeast Bioengineering Conference
01 Jan 2012
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The mechanism of flow-induced hepatocellular carcinoma cell invasion is examined in this study. The concept of autologous chemotaxis drives the focus on utilizing 3-D microenvironments to mimic and better understand the mechanism behind invasion in cancer cells. Invasion assays utilizing Boyden chambers containing a Matrigel/Type I rat tail collagen matrix simulates a 3-D microenvironment. Hepatocellular carcinoma cell lines Huh7 and MHCC97H displayed significant invasion due to interstitial flow. The increased presence of chemokine receptor CXCR4 is examined in two HCC cell lines: HepG2 and Huh7. These results support the claim that CXCR4 plays a role in cancer cell invasion and could potentially serve to better understand the mechanism of how interstitial flow increases HCC cell invasion.
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Details
- Title
- Interstitial flow drives CXCR4-dependent hepatocellular carcinoma cell invasion
- Creators
- A. D. Shah - Drexel Univ, Sch Biomed Engn Sci & Hlth Syst, Philadelphia, PA 19104 USAA. C. Shieh - Drexel UniversityIEEE
- Publication Details
- 2012 38TH ANNUAL NORTHEAST BIOENGINEERING CONFERENCE (NEBEC), pp.43-44
- Series
- Annual IEEE Northeast Bioengineering Conference
- Publisher
- IEEE
- Number of pages
- 2
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Identifiers
- 991019170502304721
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- Engineering, Biomedical
- Engineering, Electrical & Electronic