Conference proceeding
Investigating Pace of Biological Aging as a Mental and Physical Health Biomarker in Youth with Perinatally-Acquired HIV
Proceedings of the 16th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics, pp 1-1
12 Oct 2025
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
HIV and its treatment may affect the growth and development of organ function and the mental health of youth who are living with perinatally-acquired HIV (PHIV). Recent research has investigated utilizing biological age as a quantitative tool that can accurately predict a broad range of physical and mental health outcomes. However, few studies have utilized a longitudinal approach to analyze biological age in targeted populations such as those with PHIV. Even fewer studies have investigated the trends of biological aging in children since most biological aging algorithms have been developed with an older population in mind. To fill the gap, we propose a new approach to quantify the pace of biological aging as a weighted combination of the temporal trajectory of each individual biomarker. The resulting metric is called individualized pace of biological aging (IPOA). Compared to existing methods such as Belsky's pace of biological aging (BPOA), and biological age gap (BAG), our proposed IPOA allows researchers to effectively account for each participant's baseline health condition as these serve as weights in the model. Our results show that IPOA was significantly associated with future HIV viral load and multiple health outcomes, outperforming previously validated biological aging and pace of aging methods. Overall, our proposed method allows for a more accurate, data-driven method of calculating pace of aging for adolescents by utilizing a weighted combination of the starting health condition of each individual that may be clinically useful as a predictive tool of whole person health.
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Details
- Title
- Investigating Pace of Biological Aging as a Mental and Physical Health Biomarker in Youth with Perinatally-Acquired HIV
- Creators
- Hansoo Chang - Drexel UniversityAshni Kumar - Drexel University, Philadelphia, USAJoshua Suh - Drexel University, Philadelphia, USAKevin Street - Drexel UniversityAna Ferariu - Drexel UniversityAlexei Taylor - Drexel UniversityKunjal Patel - Harvard University PressSean Brummel - Harvard University PressPaige Williams - Harvard University PressLei Wang - Baycrest HospitalFengqing Zhang - Drexel University
- Publication Details
- Proceedings of the 16th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics, pp 1-1
- Conference
- BCB '25: 16th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics
- Series
- ACM Conferences
- Publisher
- ACM; NEW YORK
- Number of pages
- 1
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:001658892200085
- Other Identifier
- 991022146957804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Mathematical & Computational Biology
- Medical Informatics