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Investigation of alternating and continuous functional MRI experimental designs at 1.5 T
Conference proceeding

Investigation of alternating and continuous functional MRI experimental designs at 1.5 T

F.B Mohamed, J.I Tracy, S.H Faro, R Koenigsberg, J Emperado and A Pinus
Proceedings of the First Joint BMES/EMBS Conference. 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Annual Fall Meeting of the Biomedical Engineering Society (Cat. N, v 2, pp 1083 vol.2-1083
1999
DOI: https://doi.org/10.1109/IEMBS.1999.804243

Abstract

Analysis of variance Biomedical engineering Blood Design for experiments Fingers Magnetic resonance imaging Radiology Statistical analysis Statistics Testing
Studies the effect of two different functional MRI (fMRI) experimental design parameters on blood oxygenation level dependent (BOLD) signal contrast. The design parameters examined were: (1) the pattern of administering the control and activation conditions; and (2) the quantity of the control signals collected. Six normal volunteers underwent single finger opposition fMRI using T2*-weighted echo planar imaging technique. The BOLD signal contrast was evaluated using analysis of variance on normalized t-values and mean region-of-interest (ROI) intensity. The results demonstrate: (1) the alternating pattern of administering rest and activation epochs produced a more robust statistical difference in BOLD signal than a continuous pattern, and (2) a reduction in the amount of rest signal collected did not result in a statistically significant reduction in the BOLD signal. The results indicate that manipulating such factors of signal collection does alter BOLD signal properties.

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