Conference proceeding
Light scattering properties of kidney epithelial cells and nuclei
OPTICAL BIOPSY VI, v 6091(1), pp 609108-609109
01 Jan 2006
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Enlargement of mammalian cells nuclei due to the cancerous inflammation can be detected early through noninvasive optical techniques. We report on the results of cellular experiments, aimed towards the development of a fiber optic endoscopic probe used for precancerous detection of Barrett's esophagus. We previously presented white light scattering results from tissue phantoms (polystyrene polybead microspheres). In this paper, we discuss tight scattering properties of epithelial MDCK (Madine-Darby Canine Kidney) cells and cell nuclei suspensions. A bifurcated optical fiber is used for experimental illumination and signal detection. The resulting scattering spectra from the cells do not exhibit the predicted Mie theory oscillatory behavior inherent to ideally spherical scatterers, such as polystyrene microspheres. However, we are able to demonstrate that the Fourier transform spectra of the cell suspensions are well correlated with the Fourier transform spectra of cell nuclei, concluding that the dominate scatterer in the backscattering region is the nucleus. This correlation experimentally illustrates that in the backscattering region, the cell nuclei are the main scatterer in the cells of the incident light.
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Details
- Title
- Light scattering properties of kidney epithelial cells and nuclei
- Creators
- Elina A. Vitol - Drexel UniversityTimothy P. Kurzweg - Drexel UniversityBahram Nabet - Drexel University
- Contributors
- R R Alfano (Editor)A Katz (Editor)
- Publication Details
- OPTICAL BIOPSY VI, v 6091(1), pp 609108-609109
- Series
- Proceedings of SPIE
- Publisher
- Spie-Int Soc Optical Engineering
- Number of pages
- 9
- Grant note
- Pennsylvania Department of Health
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- Electrical and Computer Engineering
- Web of Science ID
- WOS:000237132300006
- Scopus ID
- 2-s2.0-33646178494
- Other Identifier
- 991019168612604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Biomedical
- Optics