Conference proceeding
Magnetic Cell Therapy for Vascular Disease
2018 INTERNATIONAL CONFERENCE LASER OPTICS (ICLO 2018), pp 542-542
16 Aug 2018
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Conference Title: 2018 International Conference Laser Optics (ICLO) Conference Start Date: 2018, June 4 Conference End Date: 2018, June 8 Conference Location: Saint Petersburg, Russia The present study evaluated the potential of magnetically mediated delivery of endothelial cells (ECs) to inhibit in-stent stenosis induced by mechanical injury in a rat carotid artery stent angioplasty model. Syngeneic ECs loaded with biodegradable polymeric magnetic nanoparticles (MNPs) were administered at the distal end of the stented artery using a brief exposure (12 min) to a uniform magnetic field (1.4-kOe). After two months, magnetic delivery of ECs demonstrated significant protection from stenosis at the distal part of the stent in the cell therapy group compared to both the proximal part of stent in the cell therapy group and the control (stented, nontreated) group: 1.7-fold (p < 0.001) less reduction in lumen diameter as measured by B-mode and color Doppler ultrasound, 2.3-fold (p < 0.001) less reduction in the ratios of peak systolic velocities as measured by pulsed wave Doppler ultrasound, and 2.1-fold (p < 0.001) attenuation of stenosis as determined through end point morphometric analysis.
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Details
- Title
- Magnetic Cell Therapy for Vascular Disease
- Creators
- B. Polyak
- Publication Details
- 2018 INTERNATIONAL CONFERENCE LASER OPTICS (ICLO 2018), pp 542-542
- Publisher
- The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
- Number of pages
- 1
- Grant note
- Drexel University College of Medicine Clinical & Translational Research Institute (CTRI) 2016-2017 Commonwealth of Pennsylvania Universal Research Enhancement (CURE) grant R01HL107771 / National Heart, Lung, and Blood Institute Award H1504 / W.W. Smith Charitable Trust
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:000451036000542
- Scopus ID
- 2-s2.0-85052533239
- Other Identifier
- 991019170330104721
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- Web of Science research areas
- Optics
- Physics, Applied