Conference proceeding
Mathematical modeling of perfluorocarbon chemical (PFC) bio-distribution during liquid ventilation of lambs
Proceedings of 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, v 2, pp 1138-1141 vol.2
1994
Abstract
Liquid ventilation, a technique through which an infant's stiff and fragile lungs are gently expanded by a synthetic liquid, has made enormous clinical progress in recent years. However, during LV, PFC vapors are known to diffuse across the alveoli and be subsequently distributed to various tissues via the arterial system. Since PFC vapors are soluble in tissue lipids, small amount of PFC is thus expected to accumulate in the tissues of the ventilated subject. In this paper, a flow-limited mathematical model, formulated on the mass-balanced principle, has been devised to predict the temporal distribution of tissue PFC concentrations. The solution to the model is dependent on blood flow and partition coefficient, and the modeling results are in general within one standard deviation of the mean experimental tissue concentrations.
Metrics
12 Record Views
Details
- Title
- Mathematical modeling of perfluorocarbon chemical (PFC) bio-distribution during liquid ventilation of lambs
- Creators
- H.H Sun - Drexel UniversityT.H ShafferA.S Tuazon
- Publication Details
- Proceedings of 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, v 2, pp 1138-1141 vol.2
- Publisher
- IEEE
- Resource Type
- Conference proceeding
- Language
- English
- Web of Science ID
- WOS:A1994BC56Q00570
- Other Identifier
- 991019353623304721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Biomedical