Conference proceeding
Measurements of vascular wall O/sub 2/ consumption following increased potassium
Proceedings of the Fifteenth Annual Northeast Bioengineering Conference, pp 245-246
1989
Abstract
Vascular wall tissue PO/sub 2/ was measured with recessed cathode microelectrodes (tip diameters <5 mu m) in either strips or perfused segments of rabbit abdominal aortas (n=10). When bathed by saline with low K/sup +/ (4 mEq/L) oxygenated at 20 kPa, the minimum wall PO/sub 2/ was 6.65+or-1.56 (S.E.) kPa for seven aortic strips and 10.38+or-0.54 kPa for 16 measurements in three perfused aortic segments. Biphasic PO/sub 2/ increased significantly above control by +0.91+or-0.21 kPa (p<0.05), decreasing below control within 1 min in most cases. After 3 min, PO/sub 2/ decreased significantly below control by -0.72+or-0.24 kPa (p<0.05). O/sub 2/ disappearance rates measured after stopping flow to perfused segments were significantly faster (p<0.001) after relatively small changes in K/sup +/ (4 to 7 mEq/L) with little further increase at higher K/sup +/ up to 30 mEq/L. The data are consistent with elevated O/sub 2/ consumption as K/sup +/ increases. Perfused aortic segments had much greater metabolic changes than aortic strips for similar K/sup +/ increases.< >
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Details
- Title
- Measurements of vascular wall O/sub 2/ consumption following increased potassium
- Creators
- D.G Buerk - Drexel UniversityS.E Dubin - Drexel UniversityK Gealow - Drexel University
- Publication Details
- Proceedings of the Fifteenth Annual Northeast Bioengineering Conference, pp 245-246
- Conference
- Fifteenth Annual Northeast Bioengineering Conference, 15th
- Publisher
- IEEE
- Number of pages
- 1
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; [Retired Faculty]
- Other Identifier
- 991019231755604721