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Microbicidal treatment of HIV-1-infected breast milk as an alternative for prevention of mother-to-child transmission of HIV-1 through breastfeeding
Conference proceeding

Microbicidal treatment of HIV-1-infected breast milk as an alternative for prevention of mother-to-child transmission of HIV-1 through breastfeeding

S Urdaneta, B Wigdahl, E B Neely, C M Berlin, C L Schengrund, H M Lin, M K Howett and MEDIMOND
XV INTERNATIONAL AIDS CONFERENCE: CLINICAL RESEARCH, TREATMENT, AND CARE, pp 135-138
01 Jan 2004
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Infectious Diseases Life Sciences & Biomedicine Pharmacology & Pharmacy Science & Technology Virology
Prevention of transmission of HIV-1 through breast milk would help reduce the number of pediatric cases of HIV/AIDS. Sodium dodecyl sulfate (SDS) is a broad spectrum alkyl sulfate microbicide that inactivates HIV-1 in vitro at low concentrations(2), and is inexpensive. Thus, alkyl sulfates may be used for microbicidal treatment of expressed HIV-1 breast milk. Within minutes of treatment, SDS (greater than or equal to 0.01%) inactivates in vitro cell-free and cell-associated virus added to breast milk. If SDS is removed after treatment, HIV-1 infectivity is not recovered. Flow cytometry revealed loss of cells upon treatment with 1% SIDS. At less than or equal to 1%, SDS decreased viral load in milk samples to undetectable levels. Alternative microbicides are currently being tested.

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#5 Gender Equality
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Web of Science research areas
Infectious Diseases
Pharmacology & Pharmacy
Virology
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