Conference proceeding
Microscopical quantification and functional simulation of pulmonary respiratory units
Proceedings of SPIE, v 2655(1), pp 234-244
10 Apr 1996
Abstract
A framework for a computer-guided image acquisition procedure in confocal microscopy is described, which allows a 9-fold increase of the field of view and an extended imaging in axial direction by scanning aligned thick serial sections. Using an image compositing technique, complete respiratory units (acini) of small mammalian species (rat, mouse) could be investigated at high resolution. The quantification of the composed volume includes segmentation and topological investigation. With the help of parameters measured, a computer model of the acinus is designed to prepare functional simulations. In order to study flow of air in the acini, diffusion and the oxygen uptake, a set of mass transport equations is solved iteratively. The structural dynamics of ventilatory units during inhalation and expiration is also included.
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Details
- Title
- Microscopical quantification and functional simulation of pulmonary respiratory units
- Creators
- Andres Kriete - Univ. Giessen (Germany)
- Publication Details
- Proceedings of SPIE, v 2655(1), pp 234-244
- Conference
- Three-Dimensional Microscopy: Image Acquisition and Processing III, 3rd
- Publisher
- Society of Photo-Optical Instrumentation Engineers (SPIE)
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:A1996BF46V00029
- Other Identifier
- 991019186686004721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Instruments & Instrumentation
- Microscopy
- Optics