Conference proceeding
Mining protein complexes based on connected affinity clique extension
The Institute of Electrical and Electronics Engineers, Inc. (IEEE) Conference Proceedings
01 Dec 2013
Abstract
Conference Title: 2013 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) Conference Start Date: 2013, Dec. 18 Conference End Date: 2013, Dec. 21 Conference Location: Shanghai, China A novel algorithm based on Connected Affinity Clique Extension (CACE) for mining overlapping functional modules in protein interaction network is proposed in this paper. In this approach, the value of protein connected affinity is interpreted as the reliability and possibility of interaction which is inferred from protein complexes. The protein interaction network is constructed as a weighted graph, and the weigh is dependent on the connected affinity coefficient. The experimental results of our CACE in two test data sets show that the CACE can detect the functional modules much more effective and accurate compared with other state-of-art algorithms CPM and IPC-MCE. [PUBLICATION ABSTRACT]
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Details
- Title
- Mining protein complexes based on connected affinity clique extension
- Creators
- Peng LiXiaohua HuTingting HeJunmin ZhaoMing ZhangXianjun Shen
- Publication Details
- The Institute of Electrical and Electronics Engineers, Inc. (IEEE) Conference Proceedings
- Publisher
- The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- Information Science (Informatics)
- Identifiers
- 991019170611204721