Conference proceeding
Modeling effects of nitric oxide on oxygen consumption in the microcirculation
Proceedings of the IEEE 28th Annual Northeast Bioengineering Conference (IEEE Cat. No.02CH37342), v 2002-, pp 31-32
2002
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Nitric oxide (NO) is a powerful vasodilator that regulates blood flow and inhibits mitochondrial oxygen (O/sub 2/) consumption. We present a mathematical model to show the effects NO has on the regulation of oxygen consumption in the microcirculation. We use expressions based on experimental data to simulate the steady state coupled mass transport of O/sub 2/ and NO through blood vessels, the vascular wall, and tissue. Our preliminary modeling studies, using a cylindrical geometry, show that the inhibition of O/sub 2/ consumption by NO increases tissue PO/sub 2/ farther from the vessel, The effect is more pronounced at lower PO/sub 2/ values.
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Details
- Title
- Modeling effects of nitric oxide on oxygen consumption in the microcirculation
- Creators
- K Lamkin-Kennard - Drexel UniversityD.G BuerkK BarbeeD WoottonD Jaron
- Publication Details
- Proceedings of the IEEE 28th Annual Northeast Bioengineering Conference (IEEE Cat. No.02CH37342), v 2002-, pp 31-32
- Publisher
- IEEE
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; [Retired Faculty]
- Web of Science ID
- WOS:000175970000016
- Other Identifier
- 991019168719704721
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- Web of Science research areas
- Engineering, Biomedical