Conference proceeding
Modification of surfactant contrast agent for targeted ultrasound imaging
2003 IEEE 29th Annual Proceedings of Bioengineering Conference, v 2003-, pp 305-306
2003
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Fibronectin peptide fragments were conjugated to a surfactant stabilized ultrasound contrast agent to develop a targeted contrast agent that enhances ultrasound imaging. The agent was modified with PEG and conjugated with a generic GRGDS peptide sequences that targets integrins specific to angiogenesis. The microbubbles bound to human breast cancer cells in vitro within 3 minutes under flow conditions. The GRGDS peptide modified-microbubbles show promise as candidates for targeted therapeutic imaging and eventually drug delivery vehicles.
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Details
- Title
- Modification of surfactant contrast agent for targeted ultrasound imaging
- Creators
- B.E Oeffinger - Drexel UniversityJ.D Lathia - Drexel UniversityN.O Dhoot - Drexel UniversityK.A Barbee - Drexel UniversityM.A Wheatley - Drexel University
- Publication Details
- 2003 IEEE 29th Annual Proceedings of Bioengineering Conference, v 2003-, pp 305-306
- Publisher
- IEEE
- Resource Type
- Conference proceeding
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000184414900151
- Other Identifier
- 991019170494404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Computer Science, Artificial Intelligence
- Engineering, Biomedical
- Instruments & Instrumentation
- Radiology, Nuclear Medicine & Medical Imaging