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Modulation of vascular tone and hemostasis by serotonin and ATP
Conference proceeding   Peer reviewed

Modulation of vascular tone and hemostasis by serotonin and ATP

Gerald Soslau, Janet Parker, Robert Marcus and Isadore Brodsky
Biological Actions of Extracellular ATP, v 603, pp 429-431
01 Jan 1990

Abstract

Biology Life Sciences & Biomedicine Life Sciences & Biomedicine - Other Topics Science & Technology
Platelet serotonin and ATP may participate significantly in the maintenance of vascular tone and hemostatic processes under normal and pathological conditions. We have previously shown that extracellular ATP may modulate platelet function by phosphorylation of surface proteins and increasing cAMP levels.’ Bleeding times were found to correlate with platelet release of ATP and serotonin content in renal failure patients2 To further explore the function of serotonin and ATP within the circulatory system, we analyzed their effect on platelet aggregation and arterial contraction.

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